Fertile offspring produced from sterile mice using iPS cells

Researchers at Kyoto University have succeeded in producing fertile offspring from sterile mice with chromosome abnormality by using iPS cells, the university said Friday.The research outcome by the international team was published online by the U.S. magazine Science with the headline "Fertile offspring from sterile sex chromosome trisomic mice."The team intentionally produced sterile trisomic mice and showed that fibroblasts from the abnormal mice lose the extra sex chromosome during reprogramming to induced pluripotent stem cells, or iPS cells.The team termed the phenomenon trisomy-biased…READ FULL ARTICLE